CORYLININ
Corylifol A
CAS: 775351-88-7
Molecular Formula: C25H26O4
CORYLININ - Names and Identifiers
| Name | Corylifol A |
| Synonyms | Corylinin CORYLININ Corylifol A CORYLIFOL A 7-Dimethyl-2 3-[3-[(2E)-3 3'-GERANYL-4',7-DIHYDROXYISOFLAVONE 3'-Geranyl-4',7-dihydroxyisoflavone 6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one 3-[3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one |
| CAS | 775351-88-7 |
CORYLININ - Physico-chemical Properties
| Molecular Formula | C25H26O4 |
| Molar Mass | 390.47 |
| Density | 1.191 |
| Boling Point | 609.3±55.0 °C(Predicted) |
| pKa | 6.92±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC 50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC 50 s ranging between 4.2 and 38.4 μM. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low K i values ranging from 0.62 μM to 3.89 μM. |
CORYLININ - Reference
| Reference Show more | 1. Fan Lingqiu Xinsong Gao Yang et al. Simultaneous determination of 10 components in Psoralea corylifolia L. By HPLC [J]. Journal of Qiqihar Medical College, 2018, 39(16):73-76. 2. [IF = 3.267] Zhi-Jing Chen et al."Dietary Total prenylflavonoids from the Fruits of psoralea corylifolia L. Prevent Age-Related Cognitive failures and Down-regulations Alzheimer's Markers in SAMP8 Mice."Molecules. 2018 Jan;23(1):196 3. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 |
CORYLININ - Reference Information
| biological activity | Corylifol A can inhibit the activation and phosphorylation of STAT3 induced by IL-6, and its IC50 value is 0.81 μM. |
| target | STAT3 0.81 μM (IC 50 ) |
| in vitro study | Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC 50 value of 0.81±0.15 μ M, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells. Corylifol A inhibits SARA PLPro in a Dose-dependent manner with IC 50 s ranging between 4.2 and 38.4 μ m. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low K I values ranging from 0.62 μ m to 3.89 μ m. |
Last Update：2024-04-10 22:29:15
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Product Name: Corylifol A Visit Supplier Webpage Request for quotationCAS: 775351-88-7
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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